Conference Program:
Venue: McNamara Alumni Center, University of Minnesota
Updated: July 11, 2017
THURSDAY JULY 13TH
Genome Writers Guild Society Business Meeting - ALL MEMBERS ARE WELCOME
10:00 AM - 11:59AM Build the Guild! - finishing the paperwork on our 501c(3)
Location: The Lions Research Building/Mcguire Translational Research Facility (LRB/MTRF) Room 1-109 University of Minnesota CLICK HERE FOR A MAP
GWG17 Science Conference - McNamara Alumni Center, University of Minnesota
1:00 PM Welcome & Introduction
Allen S. Levine, Professor and Vice President for Research, University of Minnesota
SESSION A: GE from Synthetic Genomes to Species Barriers
Session Chair: Perry Hackett
1:15 - 1:45 PM Invited Speaker: Joel Bader - Mistakes were made
1:45 - 2:05 PM Selected Oral Speaker: Maciej Maselko - Engineering Species-Like Barriers: A New Paradigm for Genetic Biocontainment and Biocontrol
2:05 - 2:20 PM Flash Talks: 3 min each
Kelsie Becklin - Validation of osteosarcoma oncogenes using a medium throughput screen
Emily Camilleri - Sleeping Beauty transposon mutagenesis screen for chemotherapy resistance mechanisms in osteosarcoma
Nicholas Slipek- CRISPR/Cas9 Screen for TSGs in Osteosarcoma
Kyle Williams - Exploiting novel vulnerabilities in NF1-associated tumorigenesis: A small molecule screen identifies compounds capable of selectively killing NF1 deficient human Schwann cells
Gabriel Martínez-Gálvez - MEDJED – A method for predicting microhomology-mediated end joining (MMEJ) activation and editing outcomes
2:20 - 3:20 PM Poster Session 1
SESSION B: Immunology and Infection
Session Chair: Hind Fadel
3:20 - 3:50 PM Invited Speaker: Hind Fadel - Investigating HIV-host Factors Interaction Using Genome Engineering
3:50 - 4:10 PM Selected Oral Speaker: Emily Pomeroy - CRISPR/Cas9 editing of human primary NK cells for preclinical ovarian cancer therapy
4:10 – 4:30 PM Selected Oral Speaker: Szu-Yi Hsu - Re-designing Natural Product Biosynthesis in Streptomyces
4:30 – 5:00 PM GWG Enrichment Activity: Douglas Corley – Biotechnology in China
5:00 – 6:30 PM DINNER BREAK – On your own, Campustown area
PLENARY SESSION: Social Responsibility and Nurturing the Human Spirit
6:30 – 6:50 PM TED-style talk: Perry Hackett - The Promises and Uncertainties of Genome Editing in Animals in the 21st Century
6:50 – 7:10 PM TED-style talk: Aidas Nasevicius - Glo-ing the Distance in Animal Biotechnology
7:15 – 7:30 PM Break
7:30 – 8:30 PM Keynote Speaker: David Brin - Hard choices in human genetic engineering
8:30 - 9:30 PM Reception and book signing, Refreshments provided.
FRIDAY JULY 14TH
SESSION C: Technology I
Session Chair: Drena Dobbs
8:00 - 8:20 AM Invited Speaker: Karl Clark - Genome Engineering Provides Clues to Medical Mysteries Shortening the Diagnostic Odyssey
8:20 - 8:40 AM Selected Oral Speaker: Jordan Welker - pGTAG and pPRISM: two expanded tool sets for using short regions of homology for precise DNA integration in CRISPR compatible systems
8:40 - 9:00 AM Invited Speaker: Aron Geurts - Transforming a Laboratory Species Through Genome Engineering
9:00 – 9:20 AM Invited Speaker: Stephen Ekker - Modifying the powerhouse of the cell
9:20 - 10:00 AM Coffee Break
SESSION D: Technology II
Session Chair: Jeff Essner
10:00 - 10:20 AM Invited Speaker: Jeffery Essner - Using Short Regions of Homology for Precise DNA Integration in Zebrafish
10:20 - 10:40 AM Selected Oral Speaker: Mark Behlke - High Fidelity Genome Editing Using RNP Complexes with a Novel Mutant HiFi Cas9
10:40 - 11:00 AM Selected Oral Speaker: Amber St. Martin - Single nucleotide editing using chimeric APOBEC-Cas9 Complexes
11:00 – 11:30 AM Invited Speaker: Eric Hendrickson - The Mechanisms of Precise Genome Editing using Oligonucleotide Donors
11:30 - 11:59 AM Midwest GWG Consortia Planning - Dr. David Brown , Prolocutor, Institutional Membership GWG
12:00 - 1:00 PM GWG Enrichment: Public Perceptions - Tammy Lee Stanoch
Box lunches provided by D’Amico catering
REGULATORY SESSION: Implementing the Future
1:00 - 1:30 PM Invited Speakers:
Leili Fatehi – Re-engineering Ethics: The Need for Ethics and Governance Innovation at the Convergence of Engineering and the Life Science
Alexandra J. Greenberg – Gene Editing & the Path Forward: Thoughts from a Translational Integrator
Neil Hoffman – Regulatory Thoughts
1:30 - 2:00 PM Panel Discussion
SESSION E: Engineering Food Sources
Session Chair: Erik Vollbrecht
2:00 - 2:20 PM Selected Oral Speaker: Junqi Liu - An Improved Method for Investigating Gene Functions in Soybean Roots Using CRISPR/Cas9 and Composite Plants
2:20 - 2:40 PM Selected Oral Speaker: Shaun Curtin - CRISPR/Cas9 Mediated Mutagenesis of Soybean, Medicago and Wheat Crops
2:40 - 3:00 PM Flash Talks: 3 min each
Alaa Koleilat - Using genome editing to make zebrafish disease models of hearing loss
Sara Isakson - The genetically engineered minipig as a preclinical model of Neurofibromatosis Type I syndrome-associated nervous system tumors
Emily Julik - Lethal mutagenesis of HIV-1 induced by 5-aza-2’-deoxycytidine in human primary CD4+ T cells
Alex Larsson - TraSiR: Designing a Trans-Splicing Reporter to Detect Genetic Edits in Living Cells
Hirotaka Ata - Deciphering logics for activating Microhomology-Mediated End Joining In-vivo
3:00 - 3:30 PM Coffee Break
SESSION F: New Cellular Therapeutics Through Genome Engineering
session Chair: Aron Geurts
3:30 - 4:00 PM Invited Speaker: Laurence Cooper - Harnessing the immune system from the bench to bedside to boardroom
4:00 - 4:20 PM Selected Oral Speaker: Madhusudan V. Peshwa - Autologous Gene-corrected Hematopoietic Stem Cells as Potential Treatment for X-linked Chronic Granulomatous Disease
4:20 - 4:50 PM Invited Speaker: Julianne Smith - Waging War Against Cancer through Genome Engineering
5:00 - 6:00 Poster Session 2 - Johnson and University Halls, McNamara
6:00 - 8:00 PM CATERED DINNER in Johnson and University Halls, McNamara– Provided by GWG & D’Amico Catering
VISUAL SESSION: Building the GWG
Dinner Activity: Invited Artist: Lynn Fellman – Building the Helix, a visualization of the GWG
SATURDAY JULY 15TH
GWG Enrichment: Federal Regulatory Perspectives on Biotech Innovation
8:00 - 9:00 AM Congressman Emmer
SESSION G: Cancer Discovery
Session Chair: Maura McGrail
9:00 - 9:30 AM Invited Speaker: David Largaespada - Tracking Down Cancer Using Transposon Mutagenesis and Targeted Nucleases
9:30 - 9:50 AM Selected Oral Speaker: Lisa Koodie - Adenovirus-based Radioiodine Therapy and Imaging for Pancreatic Cancer
9:50 - 10:10 AM Invited Speaker: Maura McGrail - Editing the Editors: Targeting Transcriptional Regulators in RB Tumor Suppression
10:10 - 10:40 AM Coffee Break
SESSION H: New Therapeutics
Session Chair: David Largaespada
10:40 - 11:10 AM Invited Speaker: Alan Marmorstein - Engineering iPSC to Novel Therapeutics for Eye Diseases
11:10 - 11:30 AM Selected Oral Speaker: Caitlin Van Lith - Ex vivo hepatocyte-directed gene repair in a mouse model of metabolic liver disease
11:30 - 11:59 AM Invited Speaker: Scott McIvor - Gene Transfer and Genome Engineering Strategies for Therapy of Metabolic Disease
12:00 Noon Closing remarks and Adjourn
OPTIONAL SESSION: GWG Networking
Noon – 5:00 PM In the long-standing tradition of prior genome engineering events at the UM, please join us for a networking event at Stub & Herbs following the conference. Lunch on your own.