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Thursday, 19th of July

Pre-Meeting Genome Writers Guild Planning
Room 3-150, Cancer Cardiovascular Research Building

9:00-9:30am
GWG executive committee meeting
9:30-11:00am
GWG Society meeting

Formal Start of Conference
Memorial Hall, McNamara Building

12:00-12:05pm
Welcome
David Largaespada, PhD
12:10-12:15pm
Introduction
Jakub Tolar, MD, PhD

Session I: New Engineering Technologies

12:15-12:45pm
"Orthogonal Cas9-Cas9 Fusions Provide a Versatile Platform for Precise Genome Editing"
Scot A Wolfe, PhD (University of Massachusetts Medical School)
12:45-1:00pm
"A novel multiplexed amplicon-based NGS method to assess CRISPR off-target editing"
Selected Oral Speaker: Mark Behlke, MD, PhD
1:00-1:30pm
"Genome Engineering of Primary Cells using Base Editor Technology"
Branden Moriarity, PhD (University of Minnesota)

Session II: Cell and Gene Therapies I

1:30-2:00pm
"How to build a Registry of Regenerative Medicine Outcomes: The Carrot and the Stick"
Martin Maiers MS (Be The Match)
2:00-2:30pm
"Stem Cells in 3D: How organoids illuminate development, disease, and design"
William Hoffman MA (University of Minnesota)
2:30-3:00pm
"Nonviral synthetic polymers promote cellular and in vivo delivery of nucleic acids and genome editing"
Theresa M Reineke PhD (University of Minnesota)

Flash Talks

3:00-3:15pm
(3 x 5 mins each) from selected abstracts
Sergey Prykhozhij "Optimized knock-in of point mutations in zebrafish using CRISPR/Cas9"
Kyle Williams, PhD "New therapeutics for NF1-associated tumors and malignancies: Genetic and pharmacologic vulnerabilities"
Eric Aird "Enhancing genome editing efficiency by tethering DNA to Cas9"

Poster Session I

3:15-4:30pm
From selected abstracts

Session III: Synthetic Biology

4:30-5:00pm
"Development of a robust and scalable genetic system for Aedes aegypti population suppression"
Maciej Maselko, PhD (University of Minnesota)
5:00-5:15pm
"Dynamic Mapping of Genomic Architecture in Vivo"
Speaker selected from abstracts: Dushyant Mehra
5:15-5:45pm
"Bioengineering with synthetic cells"
Kate Adamala, PhD (University of Minnesota)

Dinner Break

5:45-7:00pm
On your own, campus area

TED Style Talks

7:00-7:15pm
"Genome writers, what are we trying to say?"
David J Odde, PhD (University of Minnesota)
7:15-7:30pm
"We Want Our Genome Story Now!"
Lynn Fellman (Fellman Studio Inc.)

Keynote Speaker

7:30-8:30pm
"Genome Editing and the DIYbio Community"
Ellen Jorgenson (Biotech Without Borders)

Friday, 20th of July

Conference Day 2
Alumni Hall, McNamara Building

Session IV: Plant Genome Engineering

8:30-9:00am
"Accelerated plant breeding using CRISPR-Cas technology"
Sergei Svitashev, PhD (DuPont)
9:00-9:15am
"CRISPR/Cas9-Mediated Mutagenesis in Soybean: from Single to Multiplexing CRISPR Targets"
Speaker selected from abstracts: Junqi Liu
9:15-9:45am
"Discovery and Application of Novel CRISPR Nucleases"
Matthew Begemann, PhD (Benson Hill Biosystems)

Session V: Regulatory Issues and Education

9:45-10:15am
"Earning Consumer Trust Through Shared Values"
Charlie Arnot (The Center for Food Integrity)
10:15-10:45am
"USDA Regulatory Approach to Plant Breeding Innovation"
Neil E Hoffman (USDA)
10:45-11:15am
"Engaging diverse voices in the era of genome editing"
Johnny Kung (Harvard Medical School)
11:15-11:45am
"This Little Piggy Went to Market; This Hornless Cow Made Milk: Gaining Regulatory Approval for Precision-Bred Food Animals"
Tammy Lee, MBA (Recombinetics)

Box lunch / Enrichment Activity

Session VI: Cell and Gene Therapies II

1:15-1:45pm
"Zinc finger nuclease-mediated ex vivo and in vivo genome editing for potential therapeutics"
Anthony Conway (Sangamo)
1:45-2:15pm
"Genetic Engineering of Human Stem Cells using Genome Editing"
Matthew Porteus, MD, PhD (Stanford University)
2:15-2:30pm
"Multiplex Human T Cell Engineering by Cas9 Base Editor Technology"
Speaker selected from abstracts: Beau Webber, PhD
2:30-3:00pm
"Exogenous Regulation of Protein Expression for Control of Gene and Cell Therapies"
Jennifer L Gori, PhD (Obsidian Therapeutics)

Session VII: Functional Genomics

3:15-3:45pm
"Genome engineering to define cancer dependencies"
William C Hahn, MD, PhD (Dana-Farber Cancer Institute)
3:45-4:15pm
"High Efficiency Genome Editing Guided by Targeted Deep Sequencing"
Shondra Pruett-Miller, PhD (St. Jude’s Children's Research Hospital)
4:15-4:30pm
"RNA-Seq identifies mutually exclusive drive insertions in PI3K-hyperactive mammary carcinomas"
Speaker selected from abstracts: Emily Pope

Flash Talks

4:30-4:45pm
(3 x 5 mins each) from selected abstracts
Zachary WareJoncas "Pioneering Targeted Mitochondrial Genome Deletions Using Zebrafish"
Nicholas Slipek "Genome-wide CRISPR screen for genetic drivers of human osteosarcoma growth and metastasis"
Dennis Webster "Homozygous RBM20^R636S swine model human dilated cardiomyopathy and reveal Lou Gehrig's disease of the heart"

Poster Session II

4:45-6:00pm
From selected abstracts

Dinner Break

6:00-7:00pm
Catered Dinner

TED Style Talks

7:00-7:15pm
"Intelligent CRISPRs?"
Drena Dobbs, PhD (Iowa State University)
7:15-7:30pm
"A SLICK Way to Improve Animal Protein Production in the Tropics"
Tad Sonstegard, PhD (Recombinetics)

Keynote Speaker

7:30-8:30pm
"The impact of biology on genome enginering"
Dana Carroll, PhD (University of Utah School of Medicine)

Saturday, 21st of July

Conference Day 3
Alumni Hall, McNamara Building

Session VIII: Cell and Gene Therapies III

9:00-9:30am
"Engineering T lymphocytes to overcome tumor-dependent immunosuppression for therapeutically targeting pancreatic cancer"
Ingunn Stromness, PhD (University of Minnesota)
9:30-9:45am
"Genetic engineering of primary human NK cells for enhanced cancer immunotherapy"
Speaker selected from abstracts: Emily Pomeroy
9:45-10:15am
"Use of piggyBac transposon to manufacture Chimeric Antigen Receptor Stem Cell Memory T Cells (CAR-Tscm) with Superior Properties"
Eric Ostertag (Poseida Therapeutics)
10:15-10:30am
Coffee break

Session IX: Developmental Biology and Stem Cells

10:30-11:00am
"Increased efficiencies using homology-mediated end joining for gene targeting"
Jeffrey Essner, PhD (Iowa State University)
11:00-11:15am
"Engineering Tissue-, Cell-, and Protein-specific Staining for X-ray Microtomography"
Speaker selected from abstracts: Spencer Katz
11:15-11:45am
"From Skin to Skeletal Muscle: A Potential for Autologous Transplantation in Muscular Dystrophies"
Rita Perlingeiro, PhD (University of Minnesota)

Meeting Close

11:45am
David Largaespada

Networking and Social
Stub and Herbs
12:00pm